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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAPKAPK2
All Species:
19.09
Human Site:
S196
Identified Species:
38.18
UniProt:
P49137
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49137
NP_004750.1
400
45568
S196
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
Chimpanzee
Pan troglodytes
XP_001164988
400
45519
S196
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
Rhesus Macaque
Macaca mulatta
XP_001085549
402
45637
S198
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
Dog
Lupus familis
XP_547382
307
35404
E120
T
D
F
G
F
A
K
E
T
T
S
H
N
S
L
Cat
Felis silvestris
Mouse
Mus musculus
P49138
386
44031
S182
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
Rat
Rattus norvegicus
Q66H84
384
43204
T177
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520888
313
36136
K125
L
T
D
F
G
F
A
K
E
T
T
T
H
N
S
Chicken
Gallus gallus
XP_417976
307
35553
E120
T
D
F
G
F
A
K
E
T
T
T
H
N
S
L
Frog
Xenopus laevis
NP_001085020
377
43533
S176
P
E
N
L
L
Y
T
S
K
R
P
N
Y
V
L
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
G228
N
L
L
Y
Y
H
P
G
A
D
S
K
I
M
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49071
359
41383
K168
L
T
D
F
G
F
A
K
E
T
F
T
S
Y
T
Honey Bee
Apis mellifera
XP_394995
421
48401
K212
P
E
N
L
L
Y
S
K
P
D
S
T
G
I
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.7
76.2
N.A.
93.2
65.5
N.A.
75.5
71.5
81.2
27.7
N.A.
55.7
55.5
N.A.
N.A.
Protein Similarity:
100
99.7
98.7
76.5
N.A.
94.7
79.2
N.A.
77
73.7
86
46.2
N.A.
71.2
70
N.A.
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
100
6.6
N.A.
0
6.6
86.6
0
N.A.
0
53.3
N.A.
N.A.
P-Site Similarity:
100
100
100
20
N.A.
100
26.6
N.A.
20
20
93.3
20
N.A.
26.6
60
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
17
17
0
9
0
0
0
34
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
17
17
0
0
0
0
0
0
17
0
0
9
0
0
% D
% Glu:
0
50
9
0
0
0
0
17
17
0
9
0
0
0
0
% E
% Phe:
0
0
17
17
17
17
0
0
0
0
9
0
0
0
0
% F
% Gly:
0
0
0
17
17
0
0
9
0
0
0
0
9
0
0
% G
% His:
0
0
0
0
0
9
0
0
0
0
0
17
9
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
9
42
9
% I
% Lys:
9
0
0
0
0
0
17
25
42
9
0
17
0
0
0
% K
% Leu:
17
9
9
50
59
9
0
0
0
0
0
0
0
0
67
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% M
% Asn:
9
0
50
9
0
0
0
0
0
0
0
42
17
9
0
% N
% Pro:
50
9
0
0
0
0
9
0
9
0
42
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
42
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
9
42
9
0
25
0
9
17
9
% S
% Thr:
17
17
0
0
0
0
42
9
17
34
17
25
0
0
9
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
9
50
9
0
0
0
0
0
9
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _